Here's my favorite. I'm always promoting it. Make The Cut, it's an inexpensive, ($60) all around design program and it's set up to cut directly to Uscutters, download the free trial. Depending on what I need to cut, (non rhinestone stuff), I will save the files and cut in Sign Cut.
I also have the Funtime Version of the Winpcsign, it's very nice as well, but it only works with my Bosskut Gazelle, what nice about this program is I can design once and cut to any of the 6 different cutters I own. (Some girls collect shoes)